Isla Santa María Vacations from $732

Book a Hotel + Flight or Car together to unlock savings

Photo by Delen Wong

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Isla Santa María Vacation

Amazing adventures await when you reserve a vacation package to Isla Santa María. Whether you're a foodie, history buff or just a traveler who loves to experience new places, there's something for everyone in this lively city. Post Office Bay is one of the top attractions to include on your sightseeing agenda during a trip to Isla Santa María. Expedia is here to help you escape the everyday. Tailor your vacation to Isla Santa María to suit your travel style, whatever that may be.

The Latest Isla Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Grand Hotel Chatham

Grand Hotel Chatham

3 out of 5
Price was $925, price is now $732 per person
$732
per person
Jul 15 - Jul 21
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
8.2/10 Very Good! (17 reviews)
I can’t say enough good things about this hotel. Clean, friendly, and comfortable don’t even begin to describe it. Easy walking distance to everything. You really can’t beat this place in San Cristobal. The staff really sets this place apart- when a cab I set up for myself didn’t show up to take me to the airport, the front desk staff dropped everything they were doing and ran out into the street to flag a cab down for me. I also forgot my AirPods and a portable charger in the room, I sent a message to the hotel when I realized expecting to be disappointed. THEY GOT THEM BACK TO ME ALL THE WAY IN THE UNITED STATES AT NO CHARGE. YOU CAN’T EVEN MAIL THINGS DIRECTLY FROM THERE TO HERE. These are honest, hardworking, dedicated people running this hotel and it shows.

Reviewed on Apr 21, 2026

Mi Playa Galapagos Beachfront

Mi Playa Galapagos Beachfront

3 out of 5
Price was $2,662, price is now $1,871 per person
$1,871
per person
Jul 2 - Jul 8
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Isla Baltra (GPS)
9.4/10 Exceptional! (8 reviews)
Mi Playa offers unobstructed view and access to the beach. It is also a big space, perfect for families.

Reviewed on Apr 13, 2026

Galapagos Eco Friendly

Galapagos Eco Friendly

3 out of 5
Price was $937, price is now $733 per person
$733
per person
Jul 15 - Jul 21
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
9.4/10 Exceptional! (236 reviews)
Harry the owner was so helpful on driving my partner to the pharmacy to get some medication for me.

Reviewed on May 27, 2026

Galapagos Coliving Ecuador Casa Tuna

Galapagos Coliving Ecuador Casa Tuna

3 out of 5
Price was $1,018, price is now $808 per person
$808
per person
Jul 15 - Jul 21
found 14 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
No reviews
Hotel Katarma Galapagos

Hotel Katarma Galapagos

3 out of 5
Price was $1,030, price is now $820 per person
$820
per person
Jul 15 - Jul 21
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
8.8/10 Excellent! (82 reviews)
Super cool artistic hotel. Reminds me of Barcelona. Short walk to the pier but far enough that it’s very quiet at night. Comfy bed, good AC! Great staff! Best market in town across the street. Would stay again.

Reviewed on Jun 5, 2025

Don't see what you're looking for?
See all available trips from Columbus to Isla Santa María
View all trips

Discover the most popular places to visit in Isla Santa María

Post Office Bay

Post Office Bay

Commune with nature and explore the great outdoors at Post Office Bay during your travels in Isla Santa María. While you're in the area, wander around the natural setting.

Post Office Bay
Punta Suarez

Punta Suarez

Explore the great outdoors at Punta Suarez, a lovely green space in Isla Santa María. Wander the seaside and white-sand beaches while you're in the area.

Punta Suarez

What to do in Isla Santa María

Learn about the history of Floreana

Full Day Floreana Tour

$220
per adult
Full Day Floreana Tour
Galapagos Enchanting 3 Islands

Galapagos Enchanting 3 Islands (5 Days)

$1,349
per adult
Galapagos Enchanting 3 Islands (5 Days)
Faune seeing at the snorkeling

Full Day Santa Fe Playa escondida snorkeling tour

$230
per adult
Full Day Santa Fe Playa escondida snorkeling tour
See all activities in Isla Santa María

Isla Santa María Hotel Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $152 total per night from May 29 to May 30
$152 total
May 29 - May 30
9/10 Wonderful! (409 reviews)
"La atencion"

Reviewed on May 27, 2026

Hotel Fiesta
Finch Bay Galapagos Hotel

Finch Bay Galapagos Hotel

4.5 out of 5
Barrio Punta Estrada Puerto Ayora Galapagos
$543 nightly
The price is $599 total per night from Jun 1 to Jun 2
$599 total
Jun 1 - Jun 2
9.4/10 Exceptional! (99 reviews)
"Highly recomended"

Reviewed on May 1, 2026

Finch Bay Galapagos Hotel
Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
$132 nightly
The price is $132 total per night from May 31 to Jun 1
$132 total
May 31 - Jun 1
10/10 Exceptional! (136 reviews)
"Highly recommend! Nico is the grandson of the owner and currently running the inn. He was so lovely, kind & helpful. He's been on all the tours himself to be able to make the best recommendations and was so great in helping us get our plans reaaranged after we missed out on a day due to not realizing ..."

Reviewed on May 27, 2026

Maidith Galapagos Inn
See all 221 properties in Isla Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Isla Santa María Vacation Packages

Isla Santa Marían Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does an Isla Santa María vacation package cost?
You can grab a vacation package to this top destination from $732 on Expedia. However, how much your vacation to Isla Santa María costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Isla Santa María?
January, August and December are great times to search for cheap Isla Santa María vacation packages. Traveling in less busy months means you can typically find reduced prices on flights and hotels.
How many days is enough for Isla Santa María?
The ideal length of your Isla Santa María vacation depends on what you'd like to see. Usually, a handful of days to a week will give you time to check out all the top sights and explore some hidden treasures along the way.
How to find the best Isla Santa María package deals?
Start your search for an Isla Santa María package deal by entering your travel dates and destination under our "Packages" tab. Then select a few filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Isla Santa María package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Isla Santa Marían escape underway.
Is it cheaper to book an Isla Santa María vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Isla Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Isla Santa María?
If you have your Isla Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are great for jetting off on a whim.
How to plan a trip to Isla Santa María?

  1. Choose your travel dates: What you want to do in Isla Santa Marían and your preferred season will help you decide when to travel.
  2. Set a budget: Factor in costs such as transportation, flights and meals when working out how much to put aside for your trip to Isla Santa María. Then, select a property that matches your budget, whether that's an affordable option or a lavish getaway.
  3. Organize your Isla Santa María getaway with Expedia's trip planning tool: Look for and book stays and things to do all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Isla Santa María together.
  4. Decide your trip length: Think about how long you want to spend exploring Isla Santa María. Plan your days so you can get to all the attractions and experiences you're interested in at a leisurely pace.
  5. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left now is to pick an Isla Santa María vacation package that brings all your bookings together.
  6. Add on experiences and excursions: Read our dedicated travel guide to find some incredible things to do in Isla Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Isla Santa María vacation packages?
If you're like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Isla Santa María trip across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can snap up cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.