Isla Santa María Vacations from $385

Book a Hotel + Flight or Car together to unlock savings

Photo by Delen Wong

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Isla Santa María Vacation

Amazing adventures await when you reserve a vacation package to Isla Santa María. Whether you're a foodie, history buff or just a traveler who loves to experience new places, there's something for everyone in this lively city. Post Office Bay is one of the top attractions to include on your sightseeing agenda during a trip to Isla Santa María. Expedia is here to help you escape the everyday. Tailor your vacation to Isla Santa María to suit your travel style, whatever that may be.

The Latest Isla Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Galapagos Planet Hotel

Galapagos Planet Hotel

3 out of 5
Price was $493, price is now $385 per person
$385
per person
Feb 9 - Feb 12
found 12 hours ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
7.6/10 Good! (40 reviews)
Very well priced, only draw back, no view at the location. But it is a short walk down to the bay area. Less than 10 minutes. Some parts of town and streets could be better maintained but it has the feel of a small town in an isolated area on an island. Many food choices a few blocks away lots of tour shops, Hotel is quiet and well maintained. Owners got us a discount on the land tour.

Reviewed on Nov 6, 2025

Casa de Nelly

Casa de Nelly

2 out of 5
Price was $616, price is now $461 per person
$461
per person
Feb 5 - Feb 9
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
8.4/10 Very Good! (6 reviews)
The Casa de Nelly team is amazing! Solidad, Roberto, and Ivan were great!

Reviewed on Jul 22, 2024

Ikala Galapagos Hotel

Ikala Galapagos Hotel

4 out of 5
Price was $791, price is now $594 per person
$594
per person
Feb 9 - Feb 12
found 12 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.6/10 Exceptional! (124 reviews)
Centrally located with lots of choices to shop and eat. A block away from The Port and plenty of taxis available. The Staff was great and their breakfasts in the morning are incredible! WiFi was a little spotty but that’s the only thing I’d change. They even packed us little snack bags for our airport run!!

Reviewed on Sep 6, 2025

Angermeyer Waterfront Inn

Angermeyer Waterfront Inn

3.5 out of 5
Price was $1,199, price is now $912 per person
$912
per person
Mar 9 - Mar 13
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.4/10 Exceptional! (122 reviews)
More 4 stars for the location, the rooms were ok, beds were extremely firm, we had an issue that was difficult to try and get resolved and never actually was resolved, food at their restaurant was great including the complementary breakfast, very nice that it’s five minutes from an amazing beach and 15 minutes from Las Grietas

Reviewed on Dec 14, 2025

Casa para vacacionar

Casa para vacacionar

3 out of 5
Price was $662, price is now $523 per person
$523
per person
Mar 1 - Mar 7
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
6.8/10 (3 reviews)
Don't see what you're looking for?
See all available trips from Columbus to Isla Santa María
View all trips

Discover the most popular places to visit in Isla Santa María

I've been spotted! A family of marine iguanas auditioning for meerkat manor #LifeAtExpedia

Punta Suarez

Explore the great outdoors at Punta Suarez, a lovely green space in Isla Santa María. Wander the seaside and white-sand beaches while you're in the area.

Punta Suarez
Swimming with sea turtles was one of the many amazing moments of my Galapagos adventure. Like most of the other animals, they went about their business without seeming to even notice the people around.

Post Office Bay

Commune with nature and explore the great outdoors at Post Office Bay during your travels in Isla Santa María. While you're in the area, wander around the natural setting.

Post Office Bay

What to do in Isla Santa María

Learn about the history of Floreana

Full Day Floreana Tour

$220
per adult
Full Day Floreana Tour
Galapagos Enchanting 3 Islands

Galapagos Enchanting 3 Islands (5 Days)

$1,329
per adult
Galapagos Enchanting 3 Islands (5 Days)
Faune seeing at the snorkeling

Full Day Santa Fe Playa escondida snorkeling tour

$220
per adult
Full Day Santa Fe Playa escondida snorkeling tour
See all activities in Isla Santa María

Isla Santa María Hotel Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $155 total per night from Jan 1 to Jan 2
$155 total
Jan 1 - Jan 2, 2026
9/10 Wonderful! (382 reviews)
Was decent.

Reviewed on Dec 20, 2025

Hotel Fiesta
Capitan Max B&B

Capitan Max B&B

3 out of 5
Charles Binford St Puerto Ayora Galapagos
$77 nightly
The price is $77 total per night from Jan 1 to Jan 2
$77 total
Jan 1 - Jan 2, 2026
9.6/10 Exceptional! (198 reviews)
A great property within walking distance from all the restaurants etc. They have a basic breakfast which does the job. The staff were very friendly and accomodating. They even allowed us to get into the room very early after our ferry arriving into Santa Cruz.

Reviewed on Dec 10, 2025

Capitan Max B&B
El Barranco Galapagos

El Barranco Galapagos

2.5 out of 5
Los colonos Puerto Ayora Galapagos
$171 nightly
The price is $171 total per night from Jan 10 to Jan 11
$171 total
Jan 10 - Jan 11, 2026
9.4/10 Exceptional! (28 reviews)
Incredible place to book your stay in Santa Cruz. Excelent service, rooms and personel.

Reviewed on Dec 9, 2025

El Barranco Galapagos
See all 208 properties in Isla Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Isla Santa María Vacation Packages

Isla Santa Marían Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does an Isla Santa María vacation package cost?
You can grab a vacation package to this top destination from $385 on Expedia. However, how much your vacation to Isla Santa María costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Isla Santa María?
January, August and December are great times to search for cheap Isla Santa María vacation packages. Traveling in less busy months means you can typically find reduced prices on flights and hotels.
How many days is enough for Isla Santa María?
The ideal length of your Isla Santa María vacation depends on what you'd like to see. Usually, a handful of days to a week will give you time to check out all the top sights and explore some hidden treasures along the way.
How to find the best Isla Santa María package deals?
Start your search for an Isla Santa María package deal by entering your travel dates and destination under our "Packages" tab. Then select a few filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Isla Santa María package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Isla Santa Marían escape underway.
Is it cheaper to book an Isla Santa María vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Isla Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Isla Santa María?
If you have your Isla Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are great for jetting off on a whim.
How to plan a trip to Isla Santa María?

  1. Choose your travel dates: What you want to do in Isla Santa Marían and your preferred season will help you decide when to travel.
  2. Set a budget: Factor in costs such as transportation, flights and meals when working out how much to put aside for your trip to Isla Santa María. Then, select a property that matches your budget, whether that's an affordable option or a lavish getaway.
  3. Organize your Isla Santa María getaway with Expedia's trip planning tool: Look for and book stays and things to do all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Isla Santa María together.
  4. Decide your trip length: Think about how long you want to spend exploring Isla Santa María. Plan your days so you can get to all the attractions and experiences you're interested in at a leisurely pace.
  5. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left now is to pick an Isla Santa María vacation package that brings all your bookings together.
  6. Add on experiences and excursions: Read our dedicated travel guide to find some incredible things to do in Isla Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Isla Santa María vacation packages?
If you're like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Isla Santa María trip across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can snap up cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.