Title: Isla Santa María Vacation Packages 2026 from $446 | Expedia.com

[Hotels in Isla Santa María](https://expedia.com/Isla-Santa-Maria-Hotels.d739209696364867584.Travel-Guide-Hotels)[Vacation Rentals in Isla Santa María](https://expedia.com/Isla-Santa-Maria-Vacation-Rentals.d739209696364867584.Travel-Guide-VacationRentals)[Car Rentals in Isla Santa María](https://expedia.com/Car-Rentals-In-Isla-Santa-Maria.d739209696364867584.Car-Rental-Guide)

![](https://images.trvl-media.com/place/553248621554455077/bde266be-4597-4eee-abb2-e62a70f719e4.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Isla Santa María Vacations from $446

## Book a Hotel + Flight or Car together to unlock savings

Photo by Delen Wong

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## Your Isla Santa María Vacation

Amazing adventures await when you reserve a vacation package to Isla Santa María. Whether you're a foodie, history buff or just a traveler who loves to experience new places, there's something for everyone in this lively city. [Post Office Bay](https://www.expedia.com/Post-Office-Bay-Galapagos.d553248621554455070.Vacation-Attraction) is one of the top attractions to include on your sightseeing agenda during a trip to Isla Santa María. Expedia is here to help you escape the everyday. Tailor your vacation to Isla Santa María to suit your travel style, whatever that may be.

## The Latest Isla Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.

![Galapagos Native](https://images.trvl-media.com/lodging/10000000/9610000/9600500/9600457/68450508_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Galapagos Native

$446

per person

Apr 27 - Apr 30

found 1 day ago

Roundtrip flight included

Guayaquil (GYE) to Isla Baltra (GPS)

7.8/10 Good! (93 reviews)

Confortablenstop over for a family

Reviewed on Dec 28, 2024

![Hotel Albemarle Galapagos Beachfront](https://images.trvl-media.com/lodging/2000000/1960000/1957300/1957249/f47b4fa8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Albemarle Galapagos Beachfront

$728

per person

Apr 20 - Apr 25

found 1 day ago

Roundtrip flight included

Quito (UIO) to Isla Baltra (GPS)

9/10 Wonderful! (91 reviews)

The staff were wonderful and did everything possible to make sure our visit was perfect.

Reviewed on Jan 8, 2026

![Angermeyer Waterfront Inn](https://images.trvl-media.com/lodging/5000000/4890000/4884900/4884897/9d038793_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Angermeyer Waterfront Inn

$586

per person

Apr 27 - Apr 30

found 1 day ago

Roundtrip flight included

Guayaquil (GYE) to Isla Baltra (GPS)

9.4/10 Exceptional! (122 reviews)

Staff very friendly and helpful. Comfortable room.

Reviewed on Jan 16, 2026

![Galapagos Sunset Hotel](https://images.trvl-media.com/lodging/16000000/15390000/15386800/15386708/62f8572b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Galapagos Sunset Hotel

$1,209

per person

Mar 27 - Apr 3

found 1 day ago

Roundtrip flight included

Guayaquil (GYE) to San Cristobal (SCY)

9.4/10 Exceptional! (168 reviews)

Room was spotless and staff was exeptionall nice.

Reviewed on Feb 2, 2026

![Royal Palm Galapagos, Curio Collection Hotel by Hilton](https://images.trvl-media.com/lodging/13000000/12540000/12535100/12535025/215f955b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Royal Palm Galapagos, Curio Collection Hotel by Hilton

Save 100% on your flight

$1,037

per person

Apr 27 - Apr 30

found 1 day ago

Roundtrip flight included

Guayaquil (GYE) to Isla Baltra (GPS)

9.2/10 Wonderful! (52 reviews)

The best part about staying at Royal Palms Galapagos was the staff. They were all friendly and helpful, making their best effort to make our stay enjoyable. They remembered our dietary restrictions and would point out if a dish had food we couldn’t eat. The facilities were very nice, and cleaned by friendly staff. The property grounds were serene and lovely. We thoroughly enjoyed our visit and would definitely choose the Royal Palms again.

Reviewed on Sep 13, 2025

Don't see what you're looking for?

See all available trips from Columbus to Isla Santa María

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-16/2026-03-23/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GPS&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_739209696364867584)

### Discover the most popular places to visit in Isla Santa María

![Swimming with sea turtles was one of the many amazing moments of my Galapagos adventure. Like most of the other animals, they went about their business without seeming to even notice the people around. ](https://images.trvl-media.com/place/553248621554455070/325aa0d2-97cf-4c55-9857-ef170ef86bb3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Post Office Bay

Commune with nature and explore the great outdoors at Post Office Bay during your travels in Isla Santa María. While you're in the area, wander around the natural setting. 

[](https://expedia.com/Post-Office-Bay-Isla-Santa-Maria.d553248621554455070.Vacation-Attraction)

![I've been spotted! A family of marine iguanas auditioning for meerkat manor #LifeAtExpedia ](https://images.trvl-media.com/place/553248621554455077/bde266be-4597-4eee-abb2-e62a70f719e4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Punta Suarez

Explore the great outdoors at Punta Suarez, a lovely green space in Isla Santa María. Wander the seaside and white-sand beaches while you're in the area. 

[](https://expedia.com/Punta-Suarez-Isla-Santa-Maria.d553248621554455077.Vacation-Attraction)

### What to do in Isla Santa María

![Learn about the history of Floreana](https://mediaim.expedia.com/localexpert/2135051/55a75ae9-35ca-4e2d-b76e-0226916a1374.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Full Day Floreana Tour

$220

per adult

[](https://expedia.com/things-to-do/full-day-floreana-tour.a2135051.activity-details)

![Galapagos Enchanting 3 Islands](https://mediaim.expedia.com/localexpert/2311367/cc73c8d2-cc66-485b-a99a-e1ebbc553293.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Galapagos Enchanting 3 Islands (5 Days)

$1,349

per adult

[](https://expedia.com/things-to-do/galapagos-enchanting-3-islands-5-days.a2311367.activity-details)

![Faune seeing at the snorkeling](https://mediaim.expedia.com/localexpert/2135374/574fafeb-77d8-4a24-b445-c1796320d30f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Full Day Santa Fe Playa escondida snorkeling tour

$220

per adult

[](https://expedia.com/things-to-do/full-day-santa-fe-playa-escondida-snorkeling-tour.a2135374.activity-details)

[See all activities in Isla Santa María](https://expedia.com/things-to-do/search?rid=739209696364867584)

## Isla Santa María Hotel Deals

![Hotel Fiesta](https://images.trvl-media.com/lodging/10000000/9700000/9690700/9690626/b440b32f_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Fiesta

Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos

$135 nightly

$135 total

Feb 28 - Mar 1

9/10 Wonderful! (390 reviews)

Great location. Staff was very friendly and helpful. Rooms were spacious and clean. Pool was refreshing after a hot day out.

Reviewed on Feb 7, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F28%2F2026&endDate=3%2F1%2F2026&selected=9690626&PinnedHotelID=9690626&HadPinnedHotel=true&regionId=739209696364867584)

![Maidith Galapagos Inn](https://images.trvl-media.com/lodging/89000000/88480000/88474700/88474681/1dd0538f_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Maidith Galapagos Inn

Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos

$126 nightly

$126 total

Feb 22 - Feb 23

9.8/10 Exceptional! (110 reviews)

Great place! Incredibly friendly and kind staff.

Reviewed on Jan 8, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=88474681&PinnedHotelID=88474681&HadPinnedHotel=true&regionId=739209696364867584)

![Ikala Galapagos Hotel](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/ecbf00ed_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Ikala Galapagos Hotel

Tomas de Berlanga 110 y Moises Brito Puerto Ayora Ecuador

$221 nightly

$243 total

Feb 28 - Mar 1

9.6/10 Exceptional! (131 reviews)

Gorgeous property and wonderful staff!

Reviewed on Jan 24, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F28%2F2026&endDate=3%2F1%2F2026&selected=23688395&PinnedHotelID=23688395&HadPinnedHotel=true&regionId=739209696364867584)

[See all 210 properties in Isla Santa María](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F17%2F2026&endDate=2%2F18%2F2026&regionId=739209696364867584)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Isla Santa María Vacation Packages

## Isla Santa Marían Essential Information

| Language      | Spanish     |
| ------------- | ----------- |
| Currency      | U.S dollars |
| Local Welcome | ¡Hola!      |
| Local Goodbye | Adiós       |

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## Frequently asked questions

### How much does an Isla Santa María vacation package cost?

### What are the cheapest months to go to Isla Santa María?

### How many days is enough for Isla Santa María?

### How to find the best Isla Santa María package deals?

### Is it cheaper to book an Isla Santa María vacation as a package?

### When to book a vacation package to Isla Santa María?

### How to plan a trip to Isla Santa María?

> 1. Choose your travel dates: What you want to do in Isla Santa Marían and your preferred season will help you decide when to travel.
> 2. Set a budget: Factor in costs such as transportation, flights and meals when working out how much to put aside for your trip to Isla Santa María. Then, select a property that matches your budget, whether that's an affordable option or a lavish getaway.
> 3. Organize your Isla Santa María getaway with Expedia's [trip planning tool](https://www.expedia.com/why/trip-planning): Look for and book stays and things to do all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Isla Santa María together.
> 4. Decide your trip length: Think about how long you want to spend exploring Isla Santa María. Plan your days so you can get to all the attractions and experiences you're interested in at a leisurely pace.
> 5. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left now is to pick an Isla Santa María vacation package that brings all your bookings together.
> 6. Add on experiences and excursions: Read our dedicated travel guide to find some incredible [things to do in Isla Santa María](https://www.expedia.com/Things-To-Do-In-Isla-Santa-Maria.d739209696364867584.Travel-Guide-Activities). Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

### Does Expedia offer Book Now, Pay Later Isla Santa María vacation packages?

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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## Go further with the Expedia app

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